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A comparative study on the effect of inhaled anesthetics on alkaline phosphatase and alanine aminotransferase serum level in nursing team and operating room personnel

Alireza Ghanbari, Farid Zand, Mehrdad Askarian, Atefeh Rahimi, Hossein Haddad Bakhodaei, Tahere Jowkar, Mahnaz Rakhshan, Mohammad Ghorbani

Background: Inhaled anesthetics are widely used drugs in health centers and hospitals. However, several side effects concerning inhalational anesthetics have been reported. Liver damage is one of the wellknown side effects of inhaled anesthetics and measurement of alkaline phosphatase and alanine aminotransferase serum level is the common method for assessing severity of these damages. Among hospital personnel, operating room team are the most exposed group to these drugs. Hence, we hypothesized that alkaline phosphatase and alanine aminotransferase serum level, should be higher in operating room personnel in comparison to other hospital personnel such as nursing team.

Results: Serum level of the enzymes in these two groups was measured and the results were analyzed statistically using SPSS software.

Conclusions: Operating room personnel showed a higher serum level of target enzymes. The results indicate that inhaled anesthetics exert more severe liver damages in operating room personnel which are more exposed to these drugs.