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A review on historical developments to current scenario of Pt complexes and their medicinal importance

Rakesh Ameta, Nitin Kumar Sharma, Man Singh

This review embraces the anticancer chemistry of platinum chemistry as well as synthesis of novel Pt complexes, specifically with reference to Pt (IV). The literature study includes earlier works on Pt (II) and (IV) complexes and their anticancer mechanism or activity. The literature studies on metal-ligand interaction at various interfaces have been summarized which includes the formation of anticancer agents through the coordination of Pt metal and nitrogen, oxygen, sulphur containing compounds as ligands. The nature, properties and anticancer activities of Pt complex as well as those of ligands have been deliberated to design new Pt chemotherapeutic complexes.