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Association of IL-18 polymorphisms with risk of polycystic ovary syndrome in a Han population of China

Qi Wang, Zongjian Tan, Hongyun Zhang, Rao Min, Zhang Cheng, Liu Wei

We aimed to investigate the association of two SNPs in the promoter region of IL-18 (IL-18-607C/A rs1946518 and -137G/C rs187238) with the risk of PCOS in a Chinese Han population. A total of 210 patients with PCOS and 408 subjects without PCOS were selected between June 2015 and December 2016. The genotyping of IL-18-607C/A rs1946518 and -137G/C rs187238 polymorphisms was carried out by an iPlex GOLD SNP genotyping analysis using the Sequenom MassARRAY® System. Unconditional multivariate logistic regression analysis was taken to calculate the relationship of IL-18-607C/A rs1946518 and -137G/C rs187238 polymorphisms with risk of PCOS. We found that BMI ≥ 24 (OR=2.78, 95% CI=1.85-4.17), ever smoking (OR=2.51, 95% CI=1.08-5.79) and ever drinking (OR=3.64, 95% CI=2.33-5.69) were associated with higher risk of PCOS. Those carrying the CC genotype were associated with 2.40 fold risk of developing PCOS (OR=2.40, 95% CI=1.22-4.72), and the GC+CC genotype displayed an increased risk of PCOS (OR=2.34, 95% CI=1.23-4.48). We suggest that IL-18-137G/C could be considered as a predictive factor for the pathogenesis of PCOS in the Han population of China.