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Changes in the level of TNF-α depending on severity in children with community-acquired pneumonia

Ardak S. Akhayeva, Dana E. Zhupenova, Tattigul A. Kenzhetayeva, Olga A. Ovsyannikova, Darya V. Karpeeva

Introduction: Community-acquired pneumonia refers to one of the most relevant infectious diseases, due to the high prevalence among the pediatric population. In last years, interest has been growing in the study of the cytokine status of the child.

Materials and Methods: In a prospective cohort study under the supervision of 110 children at the age of 5 to 14 y, of them 90 children with community-acquired pneumonia and 20 children from the control group, undergoing treatment in the respiratory department of Children's Hospital of Karaganda, in which 43.64% were girls (95% CI 31.51%-56.33%) and boys 57.27% (95% CI 34.91%-59.88%). The diagnosis of pneumonia was verified on the basis of standards ICD-10 (10th revision of the International Statistical Classification of Diseases) for diagnosis and treatment of pneumonia in children. General clinical examination was carried out in accordance with the protocols of examination of children with this pathology approved in the Republic of Kazakhstan, with the inclusion of: a bacteriological method of investigation, studies of TNF-α in serum by enzyme immunoassay.

Results: Statistical processing of the obtained results of the difference in quantitative traits marker concentrations was carried out using a nonparametric Mann-Whitney's U test.

Conclusion: The results of our study indicate that as the severity of pneumonia increases, the titers of TNF-α in the blood serum and in urine of patients increase. The results of the study in patients with bacterial pneumonia TNF-α can be used as predictors to predict the severity of pneumonia.