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Comparing systemic lupus erythematosus and two anti-histones antibodies commercial assays in an immunology.
Anjeni Nicholas
The protein parts of nucleosomes, the DNA-protein complexes that make up the substructure of transcriptionally inactive chromatin, are the target of anti-histone antibodies. They are typical of and sensitive for drug-induced lupus, where they associate with anti-ssDNA, and they are prevalent in SLE, where they associate with anti-dsDNA. Clinical correlations for anti-histone antibodies have not proven reliable due to the fact that they are frequently observed in other rheumatic disorders, such as myositis and SSc, as well as chronic infections.
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