抽象的な

Formulation in vitro and in vivo characterization of carvedilol loaded solid lipid nanoparticles.

Y Dastagiri Reddy, A B Sravani, V Ramanarayana Reddy, L Sivasanker Reddy, D Maheshwara Reddy, V Vijay kumar,G Nagarjuna Reddy

Introduction: The main aim of the present work was formulation in vitro and in vivo characterization of Carvedilol SLN’s and improve Carvedilol bioavailability. Due to high first pass effect carvedilol a beta blocker having low systemic availability (25%). Materials and Methods: Solvent injection method was used to prepare SLN’s using glycerylmonostearate (GMS) and Oleic acid as lipids, Tween 80 as Surfactant and Poloxamer 407 as Co-surfactant were used. The developed SLN’s were characterized for Particle size, Polydispersity index, Entrapment efficiency of carvedilol and TEM. Discussion: The physicochemical interaction between Carvedilol and lipid was investigated by Fourier transform infrared (FTIR) Spectroscopy and Differential Scanning Calorimeter (DSC). The release exponents showed that the value of ‘n’ was 0.993, indicating that it fallows follows zero order kinetics and Super case-II.A Comparative Pharmacokinetic studies were performed for Carvedilol Solid lipid nanoparticles and Carvedilol Suspension.