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Morita-Baylis-Hillman reaction: scope and significance

Yagyesh Kapoor, Kapil Kumar

The MBH (Morita-Baylis-Hillman) reaction has received significant and growing interest since it combines two essential necessities, namely, functional groups generation and atom economy. Indeed, the MBH reaction and its application have seen an exponential growth since last decade. Since 1990s, moreover research group have initiated work on different arena of this reaction, involving novel catalysts (particularly chiral), the scope of the substrates, understanding the mechanism and various synthetic applications of MBH adducts. The Morita-Baylis-Hillman reaction is known to be dominant tool for the construction of densely functionalized alcohols and isatin derivatives which serve as promising electrophile in this reaction.