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NSAID-induced corneal melt: Clinical importance, pathogenesis and risk mitigation.

Robert Honkanen, Wei Huang, Basil Rigas

In the age of evidence-based medicine, non-steroidal antiinflammatory drug (NSAID)-induced corneal melt (NICM) remains a standout in that its prevention, etiology and optimal management are still not guided by well-defined scientific data. NICM, the loss of corneal epithelium accompanied by stromal thinning that can result in ocular perforation and profound vision loss, remains a rare but well accepted entity. In our recent review, we examined the available literature on the clinical features and pathogenesis of NICM, and proposed measures to mitigate its impact on ocular health.