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Prognostication of outcome using coherence analysis of cerebral oxygenation in patients with sepsis associated encephalopathy

Tae Jung Kim

Sepsis-associated encephalopathy (SAE) is a multifactorial syndrome, characterized as diffuse brain dysfunction that occurs secondary to infection in the body without overt central nervous system infection. The prognosis for SAE is associated with the degree of cerebral damage. We investigated the relationship between the wavelet coherence of cerebral oxyhemoglobin (OxyHb) among different channels and outcomes in patients with SAE. 14 consecutive patients with SAE were included. Moreover, we included normal controls (n=26) for comparison. The cerebral OxyHb data were collected using functional near-infrared spectroscopy (NIRSIT, OBELAB Inc.). The coherence between sections of prefrontal OxyHb oscillations in five frequency intervals (I, 0.6–2 Hz; II, 0.15–0.6 Hz; III, 0.05–0.15 Hz; IV, 0.02–0.05 Hz; and V, 0.0095–0.02 Hz) were analyzed using wavelet coherence. In addition, we analyzed the coherence of electroencephalography (EEG) signal in three frequency intervals (delta, 2–4Hz; theta, 4–7Hz; and alpha, 8–13Hz).