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Significant improvement of hair growth and appearance by Proteoglycan Replacement Therapy with Nourkrin® Woman - An investigator-initiated, treatment satisfaction study on women with diffuse hair loss from Mexico.

Jan Wadstein*, Daniela A Guzman Sanchez, Hugo Vicente Martinez Suarez, Zaira Paulina Garcia Jimenez.

Background: Proteoglycan Replacement Therapy (PRT) is an emerging anti hair loss treatment using a proprietary complex of bioactive proteoglycans (Marilex®) to stimulate and maintain anagen in hair follicles affected by Female Pattern Hair Loss (FPHL) and Telogen Effluvium (TE). NourkrinA® woman with Marilex® (Pharma Medico Aps) works by preventing/treating proteoglycan dysmetabolism and Proteoglycan Follicular Atrophy (PFA) through augmenting the expression of follicular proteoglycans. Our objective was to evaluate the patient-reported efficacy and satisfaction from PRT with NourkrinA®. Methods: This was an observational treatment satisfaction study on 86 women (mean age=41.20 years) from Mexico with diffuse hair loss due to FPHL or TE, who voluntarily started a 6-month course of PRT with NourkrinA® woman (providing 600 mg Marilex®/day). Treatment efficacy and tolerability were assessed at mid-study and endpoint using structured, self-administered questionnaires. All phases of this study were conducted under the supervision of the World Hair Council.
Results: At baseline, 61% of volunteers had moderate-to-severe diffuse hair loss, while only 10% had a history of prior treatment. Hair growth was enhanced in 95% and 89% of patients after three and six months respectively, with prominent changes in >78%. NourkrinA® also improved hair quality/appearance in 97% of users after three months and 88% at endpoint. Importantly, this treatment raised the level of self-confidence in 8/10 of patients. Overall, treatment satisfaction rate in this cohort was 94% at month three and 89% at month six. No clinically significant side effects were reported during the course of the study.
Conclusions: This research suggests that NourkrinA® woman with Marilex® has positive effects on hair growth and appearance in women with FPHL and TE, which begin to emerge after three months of treatment. Treating hair loss with NourkrinA® woman can also improve self-confidence in the majority of patients. Overall, the level of treatment satisfaction was exceptionally high in this study at both time points.