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Synthesis and antidementia effects of a new Zn(II) coordination polymer

Chuan-Lai Han, Rong Fu, Wei-Fu Lei

A new 2D layered framework structure, namely, {[Zn(TPA)2](DMA)3}n (1, HTPA=4-(1,2,4-triazol-4-yl)- phenylacetic acid; DMA=N,N-Dimethylacetamide) were obtained under solvothermal conditions and structurally characterized. The X-ray studies shown that 1 possess a stair-shaped 2D (4, 4) network. In addition, cholinesterase inhibitory activities in vitro of the title compound and its corresponding organic ligand toward Glutaminyl cyclase (GC), Neprilysin (NeP) and Acetylcholine esterase (AChE) were further determined.