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The effect of XRCC3 rs861539 polymorphism on the risk of head and neck squamous cell carcinoma: a systematic review and meta-analysis

Rongxing Li, Yuqing Wen, Zhou Lin, Yanping Zhang, Qiusheng Li

Background: Some studies suggested that XRCC3 rs861539 polymorphism might change the risk of Head and Neck Squamous Cell Carcinoma (HNSCC). However, other studies have reported negative results. Therefore, we did this meta-analysis to investigate the role of XRCC3 rs861539 polymorphism on HNSCC risk.

Methods and Materials: Online electronic databases (PubMed, EMBASE and Wang fang database) were searched. The strength of association was assessed by calculating Odds Ratio (OR) with 95% Confidence Interval (CI).

Results: A total of 5 studies with 868 cases and 1477 controls on the association between XRCC3 rs861539 polymorphism and HNSCC risk were included in this meta-analysis. Individuals with XRCC3 rs861539 polymorphism had an increased HNSCC risk (OR=1.65; 95% CI, 1.03-2.64; P=0.04). Subgroup analysis was performed according to smoking status. Light smokers with XRCC3 rs861539 polymorphism did not had an increased HNSCC risk (OR=3.73; 95% CI, 0.87-16.07; P=0.08). However, moderate smokers (OR=3.20; 95% CI, 1.79-5.70; P<0.0001) and heavy smokers (OR=3.69; 95% CI, 1.56-8.77; P=0.003) showed increased risk of HNSCC, respectively.

Conclusions: In conclusion, this study suggested that XRCC3 rs861539 polymorphism was associated with HNSCC risk.