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The role of adhesion molecules and cytokines in patients with diabetic nephropathy

Emre Avci, Sevil Uzeli

Diabetic Nephropathy (DN) is one of the major microvascular complications of diabetes mellitus. There are immune disorders observed in these patients realized with the changes on the cell adhesion molecules and the cytokine levels because of various reasons. Therefore, the simultaneous determination and evaluation of adhesion molecules (sVCAM-1, sICAM, sPCAM-I, E-selectin and P-selectin) and the levels of cytokines (IL-2 and TGF-B) in patients with DN undergoing dialysis therapy for chronic renal failure was aimed in this study. The levels of all parameters were determined by immune-enzyme assay method. Notwithstanding that the values of the parameters of sVCAM, sICAM, pCAM-I, E-selectin and P-selectin were significantly higher before and after dialysis as compared to those of control group. The values of IL-2 and TGF beta-I were found to be increased as compared to those of the control group. After the comparison of the IL-2 values obtained before and after-dialysis, the values obtained afterdialysis were determined higher as compared to those of the control group and the values obtained before-dialysis. It was determined that TGF beta-I values obtained after dialysis are decrease in the values obtained before-dialysis. In our study, it was determined that there is an increase in all values obtained after-dialysis as compared to those obtained before-dialysis. Our study reveals the relation between the dialysis and the increase obtained the parameters studied. Changes occurring in adhesion and cytokine levels of patients with diabetic nephropathy are important in terms predetermination of potential complications and role of dialysis treatment.