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The Role of Genetics in Lung Cancer: Understanding Inherited Risk Factors

Aimin Huo

Lung cancer is a devastating disease that claims the lives of millions of people every year. While smoking is a well-known risk factor for lung cancer, there are also genetic factors that can increase a person's risk for developing the disease. Understanding these inherited risk factors is crucial for developing better screening and treatment options for individuals at high risk.

One of the most well-known genetic risk factors for lung cancer is a mutation in the TP53 gene. This gene is responsible for producing a protein that helps regulate the cell cycle and prevent the formation of tumours. Mutations in TP53 can lead to uncontrolled cell growth and an increased risk of cancer. Inherited mutations in TP53 are relatively rare, but they are associated with a significantly higher risk of developing lung cancer. Individuals with this mutation are also at increased risk for other types of cancer, including breast, ovarian, and colon cancer.