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The role of glycosphingolipids in cellular function and disease pathogenesis.

Evert Veronica

Glycosphingolipids (GSLs) are complex glycolipids found in the outer leaflet of the plasma membrane of mammalian cells. They play critical roles in cellular function, including cell adhesion, signaling, differentiation, and recognition. GSLs are also implicated in the pathogenesis of many diseases, such as cancer, neurodegenerative disorders, and infectious diseases. The most common types of GSLs include gangliosides, globosides, and sulfatides, each with unique biological functions. Dysregulation of GSL metabolism has been linked to the development and progression of many diseases, including cancer and infectious diseases caused by bacteria and viruses. Further research into the role of GSLs in cellular function and disease pathogenesis may lead to the development of novel therapeutic strategies for the treatment of these diseases.