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Assessment of hypoglycemic and hypolipidemic activities of aqueous extract of Trigonella foenum-graecum in streptozotocin-induced diabetic rats

Zhiyong Zou

 Background & Aim: Diabetes mellitus is a common disease, treated either with insulin or oral anti-diabetics which have undesirable effects because of their chemical composition. As an alternative, diabetes could be treated by medicinal plants. This study aimed to assess the effects of Trigonella foenum graecum (TFG) seeds aqueous extract on biochemical parameters in streptozotocin-induced diabetic rats. Materials & Methods: A population of forty (40) rats was divided into 4 groups; normal control, experiment control (diabetic rats by STZ), diabetic treated with TFG at the dose 1 mL (100 mg/mL) and non-diabetic treated (TFG). During 30 days of experiments, body weight and biochemical parameters were measured and statistically analyzed using SigmaPlot software. Results: No significant difference in body weight was observed in diabetics animals (168??±8.5 g/L) and animals treated with TGF (167??±4.7 g/L). Significant decrease in blood glucose (1.16??±0.15 g/L), triglycerides (0.64??±0.21 g/L), serum urea (0.38??±0.19 g/L) and creatinine (8.02 mg/L) levels were reported in diabetics treated with TFG compared to diabetic animals non-treated. Conclusion: Trigonella foenum-graecum was able to regulate and maintain glycaemia and lipid profile at normal levels at diabetic animals.